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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK5
All Species:
49.39
Human Site:
T223
Identified Species:
77.62
UniProt:
Q00535
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00535
NP_004926.1
292
33304
T223
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
Chimpanzee
Pan troglodytes
XP_001149427
306
35062
S224
F
R
M
L
G
T
P
S
E
D
T
W
P
G
V
Rhesus Macaque
Macaca mulatta
XP_001102502
306
34957
S224
F
R
M
L
G
T
P
S
E
A
T
W
P
G
V
Dog
Lupus familis
XP_532760
331
37322
T262
F
R
L
L
G
T
P
T
E
E
Q
W
P
A
M
Cat
Felis silvestris
Mouse
Mus musculus
P49615
292
33270
T223
F
R
L
L
G
T
P
T
E
E
Q
W
P
A
M
Rat
Rattus norvegicus
Q03114
292
33236
T223
F
R
L
L
G
T
P
T
E
E
Q
W
P
A
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001129258
292
33321
T223
F
R
L
L
G
T
P
T
E
E
Q
W
P
A
M
Frog
Xenopus laevis
P51166
292
33320
T223
F
R
L
L
G
T
P
T
E
E
Q
W
P
A
M
Zebra Danio
Brachydanio rerio
NP_571794
292
33381
T223
F
R
L
L
G
T
P
T
E
E
Q
W
Q
T
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48609
294
33162
N223
F
R
V
L
G
T
P
N
E
D
S
W
P
G
V
Honey Bee
Apis mellifera
XP_391878
299
34094
T223
F
K
M
L
G
T
P
T
E
E
T
W
P
D
F
Nematode Worm
Caenorhab. elegans
NP_499783
292
33044
S223
F
K
Q
L
G
S
P
S
E
D
N
W
P
S
I
Sea Urchin
Strong. purpuratus
XP_001200386
295
33676
T224
F
K
L
L
G
T
P
T
E
D
T
W
P
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
N224
F
R
I
L
G
T
P
N
E
Q
S
W
P
G
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
Y224
F
R
I
M
G
T
P
Y
E
D
T
W
R
G
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.1
58.8
86.7
N.A.
99.6
99.3
N.A.
N.A.
97.2
96.9
96.5
N.A.
77.5
81.9
73.6
67.1
Protein Similarity:
100
75.1
75.1
87.9
N.A.
100
99.6
N.A.
N.A.
98.9
98.9
98.9
N.A.
86.7
89.3
86.9
78.9
P-Site Identity:
100
60
60
93.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
93.3
86.6
N.A.
60
66.6
53.3
66.6
P-Site Similarity:
100
86.6
80
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
80
80
86.6
86.6
Percent
Protein Identity:
N.A.
57.8
N.A.
56.4
N.A.
N.A.
Protein Similarity:
N.A.
76.8
N.A.
75.5
N.A.
N.A.
P-Site Identity:
N.A.
60
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
80
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
0
0
0
34
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
34
0
0
0
7
0
% D
% Glu:
0
0
0
0
0
0
0
0
100
54
0
0
0
0
0
% E
% Phe:
100
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
100
0
0
0
0
0
0
0
0
40
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
14
0
0
0
0
0
0
0
0
0
0
0
14
% I
% Lys:
0
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
54
94
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
20
7
0
0
0
0
0
0
0
0
0
0
47
% M
% Asn:
0
0
0
0
0
0
0
14
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
100
0
0
0
0
0
87
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
7
47
0
7
0
0
% Q
% Arg:
0
80
0
0
0
0
0
0
0
0
0
0
7
0
0
% R
% Ser:
0
0
0
0
0
7
0
20
0
0
14
0
0
14
0
% S
% Thr:
0
0
0
0
0
94
0
60
0
0
34
0
0
7
0
% T
% Val:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _